Novel tumor-specific polypeptide and use thereof
AssigneeGenoimmune Therapeutics Co., Ltd.
InventorsYong HOU, Shuntao LUO, Ting AN, Xiumei LIN, BO LI, Guanglei LI
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Abstract
The present invention relates to a novel tumor-specific polypeptide and use thereof. In particular, the present invention relates to a tumor-specific polypeptide having high affinity for HLA-A0201 and having cytotoxic T lymphocyte inducing ability, and its use for diagnosing, preventing and treating diseases (especially cancer) associated with high expression of the TWISTNB gene or mutation(s) in the TWISTNB gene.
Claims19
A pharmaceutical composition, comprising an isolated polypeptide or a polynucleotide encoding said polypeptide, said polypeptide comprising or consisting of the following amino acid sequence:
- (SEQ ID NO:
- 2)
- KLMGIVYKV;
- (SEQ ID NO:
- 3)
- KMMGIVYKV;
- (SEQ ID NO:
- 4)
- KLMGIVYKL;
- or
- (SEQ ID NO:
- 5)
- KMMGIVYKL,
- wherein said polypeptide has the ability of inducing cytotoxic T lymphocyte cells.
Dependencies are inferred from the claim text.