Derivative of sarsasapogenin, pharmaceutical composition and use thereof

A derivative of sarsasapogenin having a structure of formula I,

• wherein, Z is selected from a monoheterocyclyl, a diheterocyclyl, and NR1R2, the monoheterocyclyl or diheterocyclyl containing one or two heteroatoms selected from sulfur, oxygen, NH and NRa;
• R1 and R2 are each independently selected from hydrogen and substituted or unsubstituted C1-C10 alkyl, or together form a 3-8 membered ring containing one or more substituents selected from C1-C10 alkyl, C3-C10 cycloalkyl, C6-C20 aryl, C3-C14 heteroaryl, halogen, hydroxyl, amino, nitro, cyano, formyl, carboxyl, alkoxy, —CF3, —SF5 and 3-8 membered heterocyclyl containing one or more heteroatoms selected from sulfur, oxygen, NH and NRa;
• X is selected from C(Rb)(Rc), C(O), and S(O)2, Rb and Rc together form a 3-8 membered carbocyclyl or a 3-8 membered heterocyclyl containing one or more heteroatoms selected from sulfur, oxygen, N, NH and NRa, the 3-8 membered carbocyclyl or the 3-8 membered heterocyclyl being optionally substituted with one or more substituents selected from C1-C10 alkyl, C3-C10 cycloalkyl, C6-C20 aryl, C3-C14 heteroaryl, halogen, hydroxyl, amino, nitro, cyano, formyl, carboxyl, alkoxy, —CF3, —SF5 and 3-8 membered heterocyclyl containing one or two heteroatoms selected from O, S and NRa;
• Y is selected from C(Rd)(Re), C(O), and S(O)2, and Rd and Re together form a 3-8 membered ring or a 3-8 membered heterocyclyl containing one or two heteroatoms selected from sulfur, oxygen, NH and NRa;
• Ra, Rb, Rc, Rd and Re are independently selected from C1-C10 alkyl, C3-C10 cycloalkyl, C6-C20 aryl and C3-C14 heteroaryl optionally substituted with at least one substituent selected from halogen, hydroxyl, amino, nitro, cyano, formyl, carboxyl, alkoxy, —CF3, and —SF5;
• X is C(Rb)(Rc), Y is C(Rd)(Re), and Rb and Rd are connected through a chemical bond;
• n is an integer selected from 0 to 10;
• and
• m is selected from 0 and 1.