2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
AssigneeThe U.S.A., as represented by the Secretary, Department of Health and Human Services
InventorsJoel Morris, Donn G. Wishka, Omar Diego Lopez
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Abstract
Halogenated analogs of 5-aza-2′-deoxycytidine, such as halogenated analogs of 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated analogs to inhibit neoplasia are described. In some examples, the halogenated analogs have a structure according to formula Ia, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof:
Claims20
A compound according to formula Ia, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof:
- where X is halo;
- Y is hydrogen, halo, or deuterium;
- each R independently is hydrogen or deuterium;
- and
- Ra is hydrogen, deuterium, alkyl, alkoxy, amino, or halo.
Dependencies are inferred from the claim text.