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US 2022/0033381 A1Published application
3-azabicyclo[3,1,1]heptane derivative and pharmaceutical composition including same
AssigneeLG Chem, Ltd.
InventorsSung Bae LEE, Sang Yong HONG, Suk Jun YOUN
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Abstract
The present invention relates to a compound of Formula 1, a pharmaceutically acceptable salt or isomer thereof, a pharmaceutical composition including the same, and a use. The compound of Formula 1 according to the present invention has ketohexokinase (KHK) inhibitory activity, and is effectively used for preventing or treating metabolic disease such as diabetes, diabetic complications, obesity, nonalcoholic fatty liver disease, and fatty hepatitis.
Claims12
A compound of the following Formula 1, or a pharmaceutically acceptable salt or isomer thereof:
- in the Formula 1,
- R1 is a C3-C7 heterocycloalkyl containing N which is unsubstituted or substituted with C1-C3 alkyl,
- R2 is a C1-C3 alkyl which is unsubstituted or substituted with 1-5 halogen atoms,
- R3 represents —(CH2)mCO2H,
- m is an integer of 0 to 2, and
- X represents N or C—CN.
3 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.