Estrogen receptor antagonist

A compound of formula (II), an isomer thereof or a pharmaceutically acceptable salt thereof,

• wherein,
• X is selected from the group consisting of NH, O and S;
• Y is selected from the group consisting of N and CR7;
• Y1 is CH, and Y2 is N;
• or, Y1 is N, and Y2 is CH or CF;
• or, Y1 is CH, and Y2 is CH;
• L is
• ring A is selected from the group consisting of C6-10 aryl and 5-10 membered heteroaryl;
• R1 is selected from the group consisting of H, halogen, CN, COOH, NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Ra;
• R2 is selected from the group consisting of C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Rb;
• R3 is selected from the group consisting of H, halogen, CN, NO2, OH, COOH, NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Rc;
• R13 is H or
• R4 is selected from the group consisting of COOH, NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl, phenyl and 5-6 membered heteroaryl being optionally substituted with 1, 2 or 3 Rd;
• R5 is selected from the group consisting of H, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Re;
• R6, R7, R8 and R9 are each independently selected from the group consisting of H, halogen, CN, NO2, OH, COOH, NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Rf;
• R10, R11 and R12 are each independently selected from the group consisting of H, halogen, CN, NO2, OH, COOH, NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl being optionally substituted with 1, 2 or 3 Rg;
• Ra, Rb, Re, Rd, Re, Rf and Rg are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, NH2, COOH, C(═O)NH2, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl and C3-6 cycloalkyl-C1-3 alkyl-, the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl and C3-6 cycloalkyl-C1-3 alkyl- being optionally substituted with 1, 2 or 3 R;
• R is independently selected from the group consisting of F, Cl, Br, I, OH, CN, NH2, COOH, Me, Et, CF3, CHF2, CH2F, NHCH3, and N(CH3)2;
• the C1-6 heteroalkyl, 3-6 membered heterocycloalkyl and 5-6 membered heteroaryl each comprise 1, 2, 3 or 4 heteroatoms or heteroatom groups each independently selected from the group consisting of —NH—, —O—, —S—, —O—N═, —C(═O)—O—, —C(═O)—S—, —C(═O)—, —C(═S)—, —S(═O)—, —S(═O)2— and N.