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US 2022/0033372 A1Published application
Methods and compositions relating to genotoxin colibactin
AssigneePresident and Fellows of Harvard College
InventorsMatthew R. Volpe, Emily Patricia Balskus, Matthew Ryan Wilson
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Abstract
The technology described herein is directed to compounds which are substrates for ClbP, acting as fluorescent probes for ClbP activity. Further provided herein are methods for measuring ClbP activity, screening for ClbP inhibitors, detecting colibactin, and/or diagnosing cancer, which utilize the substrate compounds.
Claims18
A composition comprising a compound of Structure I:
- wherein R is alkyl, alkenyl, alkynyl, acyl, aryl, heteroaryl, cyclyl, heterocyclyl, amino, alkylamino, dialkylamino, aminoalkyl, acylamino, hydroxyl, or alkoxy, each of which can be optionally substituted with one, two, three, four or more independently selected substituents
Dependencies are inferred from the claim text.