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AssigneeGuangdong Raffles Pharmatech Co., Ltd
InventorsZhangtao ZHOU, Zhining HUANG, Weiping YE, Andrew Toroa PHILLIS
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A method for preparing (2S,3S)-3-amino-bicyclo[2.2.2]octane-2-carboxylate is in the field of pharmaceutical intermediate synthesis. The method uses 3-carbonyl-bicyclo[2.2.2]octane-2-carboxylate as the starting material and performs reductive amination, alkalinity configuration flip, and hydrogenation to remove the protecting group in sequence to obtain the target product. This synthesis method of (2S,3S)-3-amino-bicyclo[2.2.2]octane-2-carboxylate is characterized by a novel route, mild reaction conditions and low cost, with a yield of more than 65%.
Method for preparing (2S,3S)-3-amino-bicyclo[2.2.2]octane-2-carboxylate, wherein, the method comprises:
A compound of formula V, wherein, the R is methyl, ethyl, propyl, butyl, phenyl or benzyl, preferably ethyl;
A compound of formula VI, wherein, the R is methyl, ethyl, propyl, butyl, phenyl or benzyl, preferably ethyl;
Dependencies are inferred from the claim text.