Method for preparing alkynyl 2-halo-2,2-difluoroacetate
AssigneesHangzhou Transfar Fine Chemical Co., Ltd., Hangzhou Normal University, Zheijiang Transfar Functional New Material Co., Ltd.
InventorsPengfei ZHANG, Shengpeng WANG, Wanmei LI, Weiming XU, Bajin CHEN, Xiaojun WANG
Life of this patent
Estimating the term…
Abstract
A method for preparing alkynyl 2-halo-2,2-difluoroacetate is disclosed. The method comprises: subjecting a 2-halo-2,2-difluoro acetic acid, an alkynol, and a catalyst to an esterification reaction in a solvent, to obtain alkynyl 2-halo-2,2-difluoroacetate, wherein the catalyst includes one or more of sulfuric acid, phosphoric acid and p-toluenesulfonic acid.
Claims10
A method of preparing an alkynyl 2-halo-2,2-difluoroacetate, comprising:
- subjecting a 2-halo-2,2-difluoro acetic acid, an alkynol, and a catalyst to an esterification reaction in a solvent, to obtain the alkynyl 2-halo-2,2-difluoroacetate,
- wherein the 2-halo-2,2-difluoro acetic acid is 2-bromo-2,2-difluoroacetic acid or 2-chloro-2,2-difluoroacetic acid;
- wherein when the 2-halo-2,2-difluoro acetic acid is 2-bromo-2,2-difluoroacetic acid, the esterification reaction is carried out at a temperature of 60-80° C. for 5-15 h;
- the catalyst is phosphoric acid;
- a mass ratio of the 2-halo-2,2-difluoro acetic acid to the catalyst is 1:0.08-0.1;
- and a molar ratio of the 2-halo-2,2-difluoro acetic acid to the alkynol is 1:4-5;
- wherein when the 2-halo-2,2-difluoro acetic acid is 2-chloro-2,2-difluoroacetic acid, the esterification reaction is carried out at a temperature of 110-120° C. for 5-15 h;
- the catalyst is a combination of sulfuric acid and phosphoric acid;
- a mass ratio of the 2-halo-2,2-difluoro acetic acid to the catalyst is 1:0.02-0.05, and a molar ratio of the 2-halo-2,2-difluoro acetic acid to the alkynol is 1:1-4.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.