Devices and methods for sample preparation

A sample extraction device for extracting a biological analyte from a biological sampling device, comprising:

• a sample chamber configured to accept a biological sampling device;
• a reagent storage vessel, optionally mounted onto an exterior of the sample chamber;
• a lance mounted inside a lance cavity of the sample extraction device;
• a mechanism configured to apply compressive or piercing mechanical force on the reagent storage vessel, the lance or the lance cavity, and thereby push the reagent storage vessel against the lance;
• a housing component enclosing the sample chamber, the reagent storage vessel, the mechanism, and the lance;
• and
• a cap covering at least a portion of an opening of the sample chamber, the cap configured to provide controlled release of a liquid sample from the sample chamber.