Pill with needle delivery system having outwardly expanding mechanical actuation

A system comprising a mechanical actuator configured for microneedle delivery, the mechanical actuator comprising:

• a foldable biasing member comprising a first end and a second end, the foldable biasing member comprising a flexibly resilient material having a flexibility permitting the first end and the second end to be foldable toward one another for movement from an expanded state toward a collapsed state in which the mechanical actuator fits within a volume sized to fit within an ingestible capsule, the flexibly resilient material further having a resiliency that biases the first end and the second end apart from one another for movement from the collapsed state toward the expanded state;
• and
• a holder hingedly attached with the first end of the biasing member and comprising a support surface configured for supporting a carrier bearing an array of microneedles, the support surface configured for supporting the carrier for outward movement for deployment of the microneedles in response to movement from the collapsed state toward the expanded state.

A device comprising a capsule containing an array of microneedles and a launcher, wherein the device is in an ingestible form for delivery to a duodenum of a subject and releases a first shell portion and a second shell portion of the capsule from one another in response to stimuli or conditions in or en route to the duodenum, wherein the launcher drives the released first shell portion and the second shell portion away from one another to expose the array of microneedles in a position for achieving penetrating engagement with a lining of the duodenum caused by peristaltic contraction of the lining of the duodenum about the exposed array of microneedles, and wherein the penetrating engagement facilitates delivery of a payload via the microneedles.