Nasal drug delivery system

A method of delivering a substance into a subject, comprising:

• aligning a guide member relative to a first nostril of the subject via an alignment guide extending from a housing such that the alignment guide is positioned against the subject;
• inserting the guide member at least partially into the first nostril of the subject;
• advancing a flexible member through the at least one lumen of the guide member while maintaining a position of the guide member relative to the subject via the alignment guide such that a curved portion of the flexible member is advanced along a tissue surface and into a middle meatus of the subject;
• and
• delivering the substance through one or more openings defined at a distal end of the curved portion and into the middle meatus.

A drug delivery system, comprising:

• a housing for carrying the substance within;
• a guide member configured for insertion at least partially into a nasal cavity of the subject, the guide member having at least one lumen defined therethrough;
• a flexible member translatable through the at least one lumen of the guide member;
• a distal portion defined along the flexible member and having one or more openings defined at a distal end of the distal portion;
• and
• an alignment guide extending from the housing such that the alignment guide and guide member define an angle configured for positioning a portion of the flexible member within a target location within the nasal cavity.

A drug delivery system, comprising:

• a housing for carrying a drug within;
• a guide member configured for insertion simultaneously at least partially into both nasal cavities of a subject, the guide member having two lumens defined therethrough for extending into a respective nasal cavity;
• at least two flexible members translatable simultaneously through a respective lumen of the guide member and into the respective nasal cavity;
• a distal portion defined along each of the at least two flexible members and having one or more openings defined at each respective distal end;
• and
• an alignment guide such that the alignment guide and guide member define an angle configured for positioning each flexible member within a predetermined position within each respective nasal cavity.