Systems and methods for reverse pressure pulse therapy delivery

A method for providing a therapy to a subject, the method including steps comprising:

• (a) monitoring the respiration cycle of the subject;
• (b) determining an exhalation of a subject based on monitoring the respiration cycle of the subject;
• (c) identifying a predetermined point in the respiration cycle relative to the exhalation;
• (d) delivering a pressure pulse to the subject at the predetermined point in the respiration cycle;
• and
• (e) following the pressure pulse, delivering the therapy to the respiratory passage of the subject to be inhaled by the subject.

A system for providing a therapy to a subject, the system comprising:

• a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respirated by the subject;
• a sensor configured to monitor the lumen and generate a signal based on the air respirated by the subject;
• a pressure pulse delivery system configured to deliver a pressure pulse along the lumen to the subject;
• a supply of therapeutic agent coupled to the lumen;
• and
• a processor configured to:
• receive the signal from the sensor;
• cause the therapeutic agent to be delivered from the supply;
• and
• following delivery of the therapeutic agent, cause the pressure pulse delivery system to deliver a pressure pulse to the subject.