Quality of a cellular graft
AssigneeSybleu Inc.
InventorDavid Koos
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Abstract
Disclosed are methods, devices, and techniques useful for enhancing function of an organ or cellular graft through photoceutical manipulation. In one embodiment a hematopoietic graft is treated with one or more wavelengths of low level laser irradiation at a sufficient energy to enhance homing and engraftment. In another embodiment the recipient long bones are treated with one or more wavelengths of low level laser irradiation at a sufficient energy to enhance chemoattraction and growth factor secretion on recipient stromal cells. Application of the invention includes areas of cellular transplants such as islet and hepatic cell grafts.
Claims37
A method of increasing efficacy of cells for use in transplantation by pretreatment of said cells prior to transplantation with laser irradiation of at least one wavelength, said wavelength(s) in a range between about 400 nanometers and about 1070 nanometers administered for a total energy of 100 μW/cm to approximately 10 W/cm cm;
- and transplanting said irradiated cells to a patient in need.
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Dependencies are inferred from the claim text.