Active Materials, Surfaces, Surface Treatments And Methods Using Inclusion Complex Formers For Pathogen Reduction

A stable photodynamic disinfection composition for treating a surface, or material including woven and non-woven fabrics and natural and synthetic fibers said composition comprising:

• (a) a first liquid;
• and,
• (b) an inclusion complex comprising a photosensitizer associated with an inclusion complex former;
• (c) wherein when applied to a surface and upon exposure to light the photosensitizer is configured to generate ROS from ambient oxygen;
• (d) whereby pathogens adjacent to the surface are killed.

A method of making a surface of an article an active surface for killing pathogens, the method comprising:

• applying a composition to the article, the composition comprising:
• (a) a polyalkyleneoxide polysiloxane having the formula:
• wherein x is from about 1 to about 8;
• n is from about 3 to about 4;
• a is from about 1 to about 15;
• b is from about 0 to about 14;
• a+b is from about 5 to about 15;
• and R is selected from the group consisting of hydrogen, an alkyl group having from about 1 to about 4 carbon atoms, and an acetyl group;
• and wherein said polyalkylene polysiloxane has a molecular weight of less than about 1,000;
• (b) a buffering agent;
• wherein said buffering agent has at least one pKa value and/or pKb value of from about 4 to about 10;
• (c) an aqueous carrier;
• (d) a photosensitizer associated with an inclusion complex former;
• (e) wherein said composition has a pH of from about 4 to about 10;
• whereby a surface of the article is coated with the component comprising the photosensitizer associated with the inclusion complex former;
• thereby providing the surface with photodynamic disinfectant properties.

A method of disinfecting a surface, the method comprising:

• treating the surface with a composition comprising:
• (a) a polyalkyleneoxide polysiloxane having the formula:
• wherein x is from about 1 to about 8;
• n is from about 3 to about 4;
• a is from about 1 to about 15;
• b is from about 0 to about 14;
• a+b is from about 5 to about 15;
• and R is selected from the group consisting of hydrogen, an alkyl group having from about 1 to about 4 carbon atoms, and an acetyl group;
• and wherein said polyalkylene polysiloxane has a molecular weight of less than about 1,000;
• (b) a buffering agent;
• wherein said buffering agent has at least one pKa value and/or pKb value of from about 4 to about 10;
• (c) an aqueous carrier;
• (d) a photosensitizer associated with an inclusion complex former;
• (e) wherein said composition has a pH of from about 4 to about 10;
• illuminating the active surface with light, having a wavelength and sufficient energy to active the photosensitizer;
• thereby creating ROS;
• wherein during illumination the active surface kill pathogens.