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US 2022/0031867 A1Published application
Glymphatic delivery by manipulating plasma osmolarity
AssigneeUniversity of Rochester
InventorsMaiken Nedergaard, Benjamin Plog, Humberto Mestre
Life of this patent
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Abstract
This invention relates to improving delivery of agents to the central nervous system.
Claims31
A method for improving delivery of a composition to a central nervous system interstitium, brain interstitium and/or a spinal cord interstitium of a subject comprising:
- (1) enhancing glymphatic system influx;
- and
- (2) delivering the composition to the central nervous system interstitium, brain interstitium and/or the spinal cord interstitium,
- wherein the step of enhancing glymphatic system influx comprises administering a hypertonic solution agent into plasma of the subject.
1 more element
3-4. (canceled)
(canceled)
A method for treating a neurological disorder in a subject, comprising
- (1) enhancing glymphatic system influx;
- and
- (2) delivering a therapeutic composition to the central nervous system interstitium, brain interstitium and/or the spinal cord interstitium,
- wherein the step of enhancing glymphatic system influx comprises administering a hypertonic solution agent into plasma of the subject.
1 more element
17-18. (canceled)
(canceled)
30-31. (canceled)
34-45. (canceled)
Dependencies are inferred from the claim text.