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US 2022/0031858 A1Published application
Novel linkers
AssigneeBicycle Tx Limited
InventorsKevin MCDONNELL, Gemma MUDD, Paul John Beswick
Life of this patent
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Abstract
The invention relates to novel linkers which comprise two or three basic, acidic or hydrophobic natural or non-natural amino acids. The invention also relates to drug conjugates comprising said linkers, to pharmaceutical compositions comprising said drug conjugates and to the use of said drug conjugates in preventing, suppressing or treating cancer.
Claims20
A linker comprising a -P3-P2-P1- moiety, wherein:
- P1 represents a basic non-natural amino acid or a derivative thereof;
- P2 represents a hydrophobic amino acid or a hydrophobic non-natural amino acid;
- and
- P3 is either absent or represents an acidic amino acid or an acidic non-natural amino acid, such that when P1 represents Cit and P2 represents Val, then P3 must represent an acidic non-natural amino acid.
1 more element
Dependencies are inferred from the claim text.