Compositions and methods relating to salts of specialized pro-resolving mediators
AssigneeThetis Pharmaceuticals LLC
InventorsFrank C. Sciavolino, Gary Mathias, Michael C. Van Zandt, Gunnar Erik Jagdmann, JR., Jessica J. Dworak
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Abstract
The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.
Claims15
1-39. (canceled)
A method for treating colon cancer in a subject in need of such treatment, the method comprising administering to the subject a pharmaceutical composition comprising a compound of Formula IV, or an enantiomer, polymorph, solvate, or hydrate thereof, and a carrier:
- wherein
- M is a divalent metal selected from magnesium (Mg2+), calcium (Ca2+), and zinc (Zn2+), A and B are each an SPM molecule selected from an E series resolvin, a D series resolvin, and their aspirin-triggered counterparts,
- R1 and R2 are each independently —(CH2)3—Y1, and —(CH2)4—Y2,
- where Y1 and Y2 are each a basic function selected from a positively charged primary amine, a positively charged secondary amine, a positively charged tertiary amine, and a positively charged guanidine,
- X1 and X2 are each independently H or CO—Z and Z is a peptide comprising 1 to 5 amino acids.
Dependencies are inferred from the claim text.