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US 2022/0031818 A1Published application
Arginase1 polypeptides
AssigneeIO Biotech ApS
InventorMads Hald Andersen
Life of this patent
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Abstract
The present invention relates to novel polypeptides, which are derived from Arginase 1. The invention also relates to polynucleotides encoding the polypeptides. The invention also relates to compositions comprising the polypeptides and polynucleotides. The invention also concerns uses of the polypeptides, polynucleotides, and compositions.
Claims12
A polypeptide consisting of any one of the following amino acid sequences:
- (SEQ ID NO:
- 1)
- a. ISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRL;
- (SEQ ID NO:
- 2)
- b. ISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKL;
- (SEQ ID NO:
- 3)
- c. ISAKDIVYIGLRDVDPGEHYILKTLGIKYFSM;
- (SEQ ID NO:
- 4)
- d. ISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSM;
- (SEQ ID NO:
- 5)
- e. ISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGK;
- (SEQ ID NO:
- 6)
- f. ISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGK;
- g. a sequence according to any one of a.-f. in which up to three amino acids are replaced by conservative substitution, provided that the said polypeptide does not exhibit significantly reduced immunogenicity to Arginase1 as compared to the polypeptide consisting of the corresponding sequence in which no substitution is made;
- or
- h. a polynucleotide encoding the polypeptide of any one of a.-g., optionally comprised within a vector.
18 more elements
Dependencies are inferred from the claim text.