Pharmaceutical compositions containing hyaluronic acid and carnosine and relative use

A method for the treatment of osteoarthritis and/or for the treatment of rheumatoid arthritis (RA), which comprises administering to a patient in need thereof a pharmaceutical composition comprising a hyaluronic acid (HA)/carnosine conjugate with a direct amide bond between the carboxyl group of hyaluronic acid and the amine group of carnosine, wherein the hyaluronic acid (HA)/carnosine conjugate is obtained by covalently conjugating the dipeptide of carnosine with hyaluronic acid by amidation with the formation of a direct amide bond between the carboxyl of HA and the amine group of carnosine, with a derivatization degree of the carboxyl group of HA higher than 25% or ranging from 30 to 100%, or ranging from 30 to 60%, or varying within the range of 35±3% or 45±5%.