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AssigneeAdaerata, Limited Partnership
InventorsMichel CAYOUETTE, Marine LACOMME
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There is provided a method of reducing neuronal microtubule binding protein Tau (Tau) levels, promoting neuronal Tau degradation and/or promoting neuronal survival, in a subject in need thereof comprising contacting the subjects neurons with an effective amount of an agent that increases a long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity, whereby neural Tau levels is reduced in the presence of the agent, the neuronal Tau degradation is promoted and/or the neuronal survival is promoted as compared to in the absence thereof. Also provided are methods of stratification based on PTB Numb isoform expression and/or activity of the subjects and compositions and kits for applying the methods.
A method of reducing neuronal microtubule binding protein Tau (Tau) levels, promoting neuronal Tau degradation and/or promoting neuronal survival, in a subject in need thereof comprising contacting the subject's neurons with an effective amount of an agent that increases a long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity, whereby neural Tau levels is reduced in the presence of the agent, the neuronal Tau degradation is promoted and/or the neuronal survival is promoted as compared to in the absence thereof.
A method for stratifying a subject having a pathological condition associated with toxic intraneuronal Tau accumulation, comprising detecting a long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity in the subject's neurons, wherein said detecting enables the stratification of the subject, preferably wherein when a reduced long PTB Numb isoform expression and/or activity is detected as compared to a reference long PTB Numb isoform expression and/or activity, the subject is included in a clinical trial for an agent that increases the long PTB Numb isoform expression and/or activity.
A composition comprising (a) an agent that increases neuronal long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity;
A kit or package comprising (A) (a) an agent that increases neuronal long phosphotyrosine-binding (PTB) Numb isoform expression and/or activity;
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Dependencies are inferred from the claim text.