Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsSamantha YUILLE, Helene SAVIGNAC, Sarah REID, Imke Elisabeth MULDER, Nicole REICHARDT, Emma RAFTIS
Life of this patent
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Abstract
The invention provides compositions comprising a bacterial strain of the species Blautia producta or Blautia coccoides, for use in therapy.
Claims21
-15. (canceled)
A method of treating one or more symptoms of a gastrointestinal inflammatory disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bacterial strain of the species Blautia producta or Blautia coccoides, wherein the bacterial strain comprises a 16s rRNA gene sequence having at least 95% sequence identity to SEQ ID NO:
- 1, wherein the one or more symptoms of the gastrointestinal inflammatory disease comprises ulcerations and/or bleeding, weight loss, poor weight gain, or increased gut permeability, and wherein the administering is effective to treat the one or more symptoms of the gastrointestinal inflammatory disease in the subject.
A pharmaceutical composition comprising a therapeutically effective amount of a bacterial strain of the species Blautia producta and a pharmaceutically acceptable excipient, diluent, or carrier;
- wherein the bacterial strain is lyophilized;
- wherein the therapeutically effective amount of the bacterial strain comprises from about 1×103 to about 1×1011 colony forming units per gram (CFU/g) with respect to the total weight of the pharmaceutical composition;
- and
- wherein the bacterial strain comprises a 16s rRNA gene sequence of SEQ ID NO:
- 1
A method of treating colitis in a subject with graft versus host disease (GVHD), comprising administering to the subject a therapeutically effective amount of a composition comprising a bacterial strain of the species Blautia producta or Blautia coccoides, wherein the bacterial strain comprises a 16s rRNA gene sequence having at least 95% sequence identity to SEQ ID NO:
- 1, and wherein the administering is effective to treat colitis in the subject with GVHD.
A method of treating one or more symptoms associated with graft versus host disease (GVHD) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bacterial strain of the species Blautia producta or Blautia coccoides, wherein the bacterial strain comprises a 16s rRNA gene sequence having at least 95% sequence identity to SEQ ID NO:
- 1, wherein the one or more symptoms associated with GVHD comprises weight loss, poor weight gain, poor skin integrity, or increased gut permeability, and wherein the administering is effective to treat the one or more symptoms associated with GVHD in the subject.
A method of treating an inflammatory or autoimmune disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bacterial strain of the species Blautia producta, wherein the bacterial strain comprises a 16s rRNA gene sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.