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US 2022/0031771 A1Published application
Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy
AssigneeIowa State University Research Foundation, Inc.
InventorsAnumantha G. Kanthasamy, Gregory Phillips, Ahmed Abdalla, Nicholas John Backes, Piyush Padhi
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Abstract
The present invention generally provides methods and compositions for the treatment of Parkinson's disease, Alzheimer's disease, depression, anxiety, and memory deficits. The invention relates to recombinant microorganisms, particularly gut-colonizing probiotics, modified to produce L-DOPA as well as microcapsules and lyophilized formulations comprising the same.
Claims22
1-38. (canceled)
A recombinant microbial cell comprising a heterologous hpaB and hpaC nucleotide sequence stably integrated into the genome of the cell.
(canceled)
Dependencies are inferred from the claim text.