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US 2022/0031744 A1Published application
Protein l for activation and expansion of chimeric antigen receptor-modified immune cells
AssigneeFUJIFILM Cellular Dynamics, Inc.
InventorsMaksym VODYANYK, Ethan McLEOD, Xin ZHANG, Wen Bo WANG
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Abstract
Provided herein are methods for the activation and expansion of T cells. Further provided are methods for the use of the T cells for therapy.
Claims53
An in vitro method for activation and/or expansion of CAR-modified immune cells comprising:
- (a) obtaining a starting population of CAR-modified immune cells;
- and
- (b) culturing said population of CAR-modified immune cells in the presence of Protein L for a sufficient period of time to produce a population of activated and/or expanded CAR-modified immune cells.
A composition comprising CAR-modified immune cells and Protein L.
Dependencies are inferred from the claim text.