Combination therapy
AssigneeImperial College Innovations Limited
InventorPeter SARKIES
Life of this patent
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Abstract
The present invention provides a therapeutic combination for use in treating an infection with a pathogen. The therapeutic combination comprises an aminoglycoside antibiotic; and a nucleic acid monoalkylating agent that substitutes a single nucleotide of a nucleic acid with an alkyl group, wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said aminoglycoside antibiotic; or wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said nucleic acid monoalkylating agent; and kits for performing said method.
Claims28
A method of treating an infection with a pathogen in a subject, said method comprising administering a therapeutic combination to the subject, wherein said therapeutic combination comprises:
- a. an aminoglycoside antibiotic;
- and
- b. a nucleic acid monoalkylating agent that substitutes a single nucleotide of a nucleic acid with an alkyl group;
- wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said aminoglycoside antibiotic;
- or
- wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said nucleic acid monoalkylating agent.
A method of in vitro disinfection, the method comprising applying an agent combination at a site comprising a pathogen, a site suspected of comprising a pathogen, or at a site at risk of comprising a pathogen, wherein said agent combination comprises:
- a. an aminoglycoside antibiotic;
- and
- b. a nucleic acid monoalkylating agent that substitutes a single nucleotide of a nucleic acid with an alkyl group;
- wherein the agent combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said aminoglycoside antibiotic;
- or
- wherein the agent combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said nucleic acid monoalkylating agent.
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A method of treating cancer in a subject, said method comprising administering a therapeutic combination to the subject, wherein said therapeutic combination comprises:
- a. an aminoglycoside antibiotic;
- and
- b. a nucleic acid monoalkylating agent that substitutes a single nucleotide of a nucleic acid with an alkyl group;
- wherein the therapeutic combination provides an enhanced suppression of a cancer when compared with an otherwise identical composition lacking said aminoglycoside antibiotic;
- or
- wherein the therapeutic combination provides an enhanced suppression of a cancer when compared with an otherwise identical composition lacking said nucleic acid monoalkylating agent.
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Dependencies are inferred from the claim text.