Back to results
US 2022/0031688 A1Published application
C-Met Modulator Pharmaceutical Compositions
AssigneeExelixis, Inc.
InventorsJo Ann Wilson, Khalid Shah
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions and unit dosage forms comprising Compound (I) are disclosed.
Claims22
1-30. (canceled)
A tablet pharmaceutical composition comprising Compound I:
- or a pharmaceutically acceptable salt thereof, and a filler, wherein Compound 1 is present in the pharmaceutical composition in an amount of from about 10 mg to about 200 mg.
A tablet pharmaceutical composition comprising Compound I:
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable filler, binder, disintegrant, glidant, and lubricant, and optionally a pharmaceutically acceptable coating, wherein Compound I is present in the pharmaceutical composition in an amount of from about 10 mg to about 200 mg.
A tablet pharmaceutical composition comprising Compound I:
- or a pharmaceutically acceptable salt thereof and lactose, hydroxypropyl cellulose, croscarmellose sodium, and magnesium stearate, wherein Compound 1 is present in the pharmaceutical composition in an amount of from about 10 mg to about 200 mg.
A tablet pharmaceutical composition comprising Compound I:
- or a pharmaceutically acceptable salt thereof, and a filler, a binder, a disintegrant, and a lubricant, wherein the tablet pharmaceutical composition is produced by a process comprising:
- 1) Delumping unmilled Compound I;
- 2) Mixing Delumped Compound I with the filler to form a mixture;
- 3) Combining the mixture with the binder to form a binder solution;
- 4) Wet high shear granulating the binder solution to produce wet screened granules;
- 5) Fluid bed drying the wet screened granules to produce dried granules;
- 6) Blending the dried granules with the disintegrant to produce an extragranular blend;
- and
- 7) Lubricating the extragranular blend with a lubricant to produce a final blend.
6 more elements
Dependencies are inferred from the claim text.