Donecopride As Neuroprotective Agent In the Treatment of Neurodegenerative Diseases

A method for preventing and/or treating a neurodegenerative disease, comprising administering to a subject in need thereof, as neuroprotective agent, a compound of the following formula (I):

• wherein:
• X represents
• a hydrogen atom, or
• a halogen atom (Hal), where (Hal) is fluorine, chlorine, bromine or iodine, or
• a straight- or branched-chain Cp(Hal)2p+1 polyhalogenoalkyl group, where p=1, 2, 3 or 4, (Hal) having the same meaning as indicated above;
• Y represents
• an oxygen atom, or
• a sulfur atom, or
• an N—R″ radical where R″ represents a hydrogen atom, an —OH radical, an —O-A radical where A represents a straight- or branched-chain C1-C6 alkyl group, in particular where A represents a methyl group, or a straight- or branched-chain CqH2q+1 alkyl radical, where q=1, 2, 3 or 4;
• m is an integer selected from 1, 2 and 3;
• n is an integer selected from 0, 1, 2 and 3;
• r and s are integers whose values are:
• r=s=0;
• or r=s=1;
• or r=s=2;
• or r=0 and s=1;
• or lastly r=0 and s=2;
• R represents
• a hydrogen atom, or
• a straight- or branched-chain C1-C5 alkyl group capable of carrying one or more F atoms;
• R′ represents
• a branched-chain C1-C6 alkyl radical, or
• a C3-C10 cycloalkyl or C5-C13 bicyclic group, capable of carrying one or more R groups and of possessing an oxygen atom, or a nitrogen atom that can be substituted by R, or a sulfur atom or a radical —SO2— or —SO—,
• as well as its enantiomers or diastereoisomers and its racemics, its acid salts, its hydrates or its solvation products.