Novel Compositions and Methods for Treating or Preventing Dermal Disorders
AssigneeDrexel University
InventorsChristian Sell, Timothy Nacarelli, Ashley Azar
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Abstract
The present invention includes compositions and methods for treating or preventing certain dermal disorders including dermal atrophy, pseudoscars, actinic keratosis, seborrheic or actinic keratoses, lentigines, focal areas of dermal thickening, and coarse wrinkles. In certain embodiments, the compositions useful within the invention comprise a therapeutically effective amount of a mTORC1 inhibitor and a dermatologically acceptable carrier.
Claims18
A method of treating or preventing an age-related dermal disorder in a mammalian subject in need thereof, the method comprising topically administering to the subject a composition comprising a therapeutically effective amount of a mTORC1 inhibitor, or a salt, solvate, enantiomer or diastereoisomer thereof, wherein the age-related dermal disorder is at least one selected form the group consisting of dermal atrophy, seborrheic or actinic keratosis, pseudoscars, lentigines, focal areas of dermal thickening, and coarse wrinkles.
A method of increasing the lifespan, preserving cell organization, or preventing or minimizing senescence of a mammalian fibroblast, the method comprising contacting the fibroblast with a composition comprising an effective amount of a mTORC1 inhibitor or a salt, solvate, enantiomer or diastereoisomer thereof.
A kit for treating or preventing an age-related dermal disorder in a mammalian subject in need thereof, the kit comprising:
- a composition comprising a therapeutically effective amount of a mTORC1 inhibitor or a salt, solvate, enantiomer or diastereoisomer thereof, an applicator, and instructions for topically administering the composition to the subject, wherein the dermal disorder is at least one selected form the group consisting of dermal atrophy, pseudoscars, seborrheic or actinic keratosis, lentigines, focal areas of dermal thickening, and coarse wrinkles.
Dependencies are inferred from the claim text.