Methods of inhibiting procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

A method of inhibiting expression or activity of procollagen-lysine, 2-oxoglutarate 5-dioxygenases 2 (PLOD2) in a cell comprising contacting the cell with or introducing into the cell an effective amount of a compound selected from the group consisting of:

• amiloride, azelastine, bazedoxifene acetate, BIBW2992, DL-carnitine, L-carnitine, cyclosporin A, dopamine, gallic acid, gemcitabine, loperamide, manidipine, marimastat, methacycline, mubritinib, P1015, P1025, P1029, palbociclib, pexidartinib, rosiglitazone, tazemetostat, tebipenem pivoxil, teneligliptin, trospium chloride, and pharmaceutically-acceptable salts thereof, wherein the contacting or introducing results in inhibition of expression or activity of the PLOD2 in the cell.