Neuroprotective compounds and methods of use
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsJon T. Njardarson, Isaac Chogii, David Townsend Smith, Edon Vitaku, Daniela C. Zarnescu, Rachel Allen
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Abstract
The present disclosure relates to methods treating a clinical condition associated with a neurodegenerative disease or locomotor dysfunction in a subject. In particular, methods include administering to the subject in need of such a treatment a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof, or a prodrug thereof, where X, Ra, Rb, R1, R2, R3, R4, and R5 are those defined herein.
Claims20
A method for treating a clinical condition associated with a neurodegenerative disease or locomotor dysfunction in a subject, said method comprising administering to the subject in need of such a treatment a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof, or a combination thereof,
- thereby treating the clinical condition associated with locomotor dysfunction in said subject,
- wherein
- R1 is hydrogen, alkyl, optionally substituted aralkyl, optionally substituted aryl, or a nitrogen protecting group;
- each of R2 and R4 is independently hydrogen, alkyl, haloalkyl, halide, vinyl, alkynyl, —CHO, —C(═O)Rc (ketone), —CO2Rd (ester), —ORe, —OSO2Rf, optionally substituted aryl and optionally substituted heteroaryl, wherein each of Rc, Rd, Re, and Rf is independently alkyl, aryl, or aralkyl;
- R3 is alkyl or haloalkyl;
- R5 is alkyl or haloalkyl;
- each of Ra and Rb is independently hydrogen or alkyl;
- and
- X is halide, CN, ORx1, NRx2Rx3 wherein each of Rx1, Rx2, Rx3 are independently hydrogen, alkyl, cycloalkyl, optionally substituted aralkyl, optionally substituted aryl.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, or a combination thereof,
- thereby treating the clinical condition associated with locomotor dysfunction in said subject,
- wherein
- R1 is hydrogen, alkyl, optionally substituted aralkyl, optionally substituted aryl, or a nitrogen protecting group;
- each of R2 and R4 is independently hydrogen, alkyl, haloalkyl, halide, vinyl, alkynyl, —CHO, —C(═O)Rc (ketone), —CO2Rd (ester), —ORe, —OSO2Rf, optionally substituted aryl and optionally substituted heteroaryl, wherein each of Rc, Rd, Re, and Rf is independently alkyl or aryl;
- R3 is alkyl or haloalkyl;
- R5 is alkyl or haloalkyl;
- each of Ra and Rb is independently hydrogen or alkyl;
- and
- X is halide, CN, ORx1, NRx2Rx3 wherein each of Rx1, Rx2, Rx3 are independently hydrogen, alkyl, cycloalkyl, optionally substituted aralkyl, optionally substituted aryl.
Dependencies are inferred from the claim text.