Use of an organometallic compound as a dna-demethylating agent
AssigneesUniversite De Lorraine, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsStéphanie GRANDEMANGE, Antonio MONARI, Philippe GROS, Pierre François CARTRON
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Abstract
Disclosed is the non-therapeutic use, as a DNA-demethylating agent, of at least one organometallic compound including an iron atom bound to two terpyridine groups. Further disclosed are method related to applying such agent as medicine.
Claims20
A method for performing DNA demethylation for non-therapeutic purposes, comprising administering a DNA-demethylating agent to a subject, the agent comprising of at least one organometallic compound comprising an iron atom bound to two terpyridine groups of following general formula (I):
- wherein:
- R1 to R6, identical or different are chosen from among:
- a hydrogen atom;
- a linear or branched alkyl chain of formula CnH2n+1 with n=1 to 12;
- a COOH group;
- an SO3H group;
- a PO3H group;
- an aromatic cycle of formula (II) to (VI) below:
- where
- Y are each independently from the others, a CH group or a nitrogen atom;
- R7 is chosen from among an OCYH2Y+1 group with y=1 to 10;
- SCwH2w+1 with w=1 to 10;
- N(CmH2m+1)2 with m=1 to 6, COOH;
- SO3H or PO2H3;
- Z designates an oxygen atom, a sulphur atom or an NH group;
- the dotted line represents a C—C bond at the level of the connection point of the aromatic cycle of formula (II) to (VI) to the terpyridine groups of the organometallic compound of formula (I);
- X− is a counterion.
A medicine comprising an organometallic compound comprising an iron atom bound to two terpyridine groups, having a general formula (I):
- wherein:
- R1 to R6, identical or different are chosen from among:
- a hydrogen atom;
- a linear or branched alkyl chain of formula CnH2n+1 with n=1 to 12;
- a COOH group;
- an SO3H group;
- a PO3H group;
- an aromatic cycle of formula (II) to (VI) below:
- where
- Y are each independently from the others, a CH group or a nitrogen atom;
- R7 is chosen from among an OCYH2Y+1 group with y=1 to 10;
- SCwH2w+1 with w=1 to 10;
- N(CmH2m+1)2 with m=1 to 6, COOH;
- SO3H or PO2H3;
- Z designates an oxygen atom, a sulphur atom or an NH group;
- the dotted line represents a C—C bond at the level of the connection point of the aromatic cycle of formula (II) to (VI) to the terpyridine groups of the organometallic compound of formula (I);
- X− is a counterion.
Dependencies are inferred from the claim text.