Radioprotective nanodrug for small intestine and preparation method thereof

Abstract

The present invention relates to a method for constructing a nanodrug with adhesion in small intestine, including activating a basic amino acid with a small molecular catalyst, adding a polysaccharide solution and reacting to obtain an amphiphilic polymer; then adding a drug solution and mixing uniformly, to obtain drug-loaded nanoparticles including a hydrophilic portion that is the basic amino acid and a hydrophobic portion that is the polysaccharide and drug, wherein the drug has radioprotective effect or can inhibit ionizing radiation-induced cell death; and adding the drug-loaded nanoparticles to a dopamine solution to obtain a nanodrug including the basic amino acid and polydopamine on the surface after the reaction. The present invention provides an oral nanodrug with adhesion in intestinal tract, and the nanodrug has good biocompatibility, adhesion in small intestine and mucus barrier penetration ability, and can withstand the acid and alkali environment in the gastrointestinal tract.

Dependencies are inferred from the claim text.