Poly(amine-co-ester) polymeric particles for selective pulmonary delivery

A delivery formulation for selective delivery to pulmonary immune cells such as macrophages and monocytes comprising nanoparticles between 100 and 500 nm average diameter, preferably between 200 and 400 nm, and comprising a polymer having the formula

• wherein n is an integer from 1-30, m, o, and p are independently integers from 1-20, x, y, and q are independently integers from 1-1000, Rx is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted alkoxy, Z and Z′ are independently O or NR′, wherein R′ is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl,
• wherein R1 and R2 are chemical entities containing a hydroxyl group, a primary amine group, a secondary amine group, a tertiary amine group, or combinations thereof.