High-purity peg lipids and uses thereof
AssigneeModernaTX, Inc.
InventorsÖrn Almarsson, Jin Lim, Eugene Cheung, Jaclyn Milton
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Abstract
The present disclosure is based, at least in part, on the discovery that high-purity PEG lipids exhibit superior physical and biological properties, particularly when used in lipid nanoparticle (LNP) formulations. Therefore, the present disclosure provides PEG lipids at a recommended purity, e.g., for use in formulations, such as LNP formulations. The present disclosure also provides LNPs comprising the high-purity PEG lipids, and methods for delivering therapeutic agents to a subject using the same.
Claims142
A plurality of compounds of Formula (I):
- or salts thereof, wherein:
- r is independently an integer from 35-55, inclusive;
- and
- the plurality of compounds has a purity of 87% or greater with respect to compounds of Formula (I).
The plurality of compounds of claim 15, comprising less than 10% of total impurities.
A lipid nanoparticle (LNP) comprising a plurality of PEG lipids, wherein the plurality of PEG lipids has a purity of 87% or greater with respect to the PEG lipid component of the LNP.
A method of preparing a compound of Formula (I):
- or a salt thereof, the method comprising reacting a compound of the formula:
- or a salt thereof, with a compound of the formula:
- or a salt thereof;
- wherein r is an integer from 35-55, inclusive.
Dependencies are inferred from the claim text.