Nanoparticle formulations and methods of their use
AssigneesThe Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology, Children's Medical Center Corporation
InventorsJeffrey M. KARP, Wen LI, Nitin JOSHI, Robert S. LANGER, Rebekah MANNIX, Jianhua QIU, Sezin ADAY
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Abstract
Disclosed are pharmaceutical compositions formulated for delivery to the brain of a subject. The compositions include a plurality of nanoparticles (NPs) containing a brain therapeutic agent, poly(lactic-co-glycolic acid) (PLGA), and a pharmaceutically acceptable excipient selected from the group consisting of a surfactant, peptide, and combinations thereof. Also disclosed are methods of their use.
Claims58
A pharmaceutical composition formulated for delivery to the brain of a subject, the composition comprising a plurality of nanoparticles (NPs) comprising a brain therapeutic agent, poly(lactic-co-glycolic acid) (PLGA), and a pharmaceutically acceptable excipient selected from the group consisting of a surfactant, peptide, and combinations thereof.
The pharmaceutical composition of claim 11, wherein the peptide is glutathione, transferrin, or a combination thereof.
A pharmaceutical composition comprising a plurality of nanoparticles (NPs) comprising a cargo molecule, a hydrophobic polymer, and a pharmaceutically acceptable excipient selected from the group consisting of a surfactant, peptide, and combinations thereof.
Dependencies are inferred from the claim text.