Ophthalmic compositions for delivering meibum-like materials
AssigneeAltaire Pharmaceuticals, Inc.
InventorAssad Sawaya
Life of this patent
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Abstract
Artificial tear formulations include nanoparticles having a nonpolar meibum-like material encapsulated by a polyoxyethylene castor oil derivative and exhibits a clear appearance. The meibum-like material may include a cholesteryl ester and/or a wax ester. The polyoxyethylene castor oil derivative may be polyoxyl 35 castor oil. The formulation, which may be a solution suitable for eye drops or a gel/ointment, may have a pH of 6.0-8.0, and an osmolality of from 250 mOsm/kg to 400 mOsm/kg.
Claims26
An artificial tear formulation comprising;
- nanoparticles having one or more nonpolar meibum-like material encapsulated by at least one polyoxyethylene castor oil derivative,
- wherein the formulation exhibits a clear appearance.
A method comprising
- administering an artificial tear formulation to a patient experiencing a dry eye condition, the formulation exhibiting a clear appearance and having nanoparticles with one or more nonpolar meibum-like material encapsulated by at least one polyoxyethylene castor oil derivative.
An artificial tear formulation comprising:
- nanoparticles having one or more pharmaceutically acceptable active agent encapsulated by at least one polyoxyethylene castor oil derivative,
- wherein the formulation exhibits a clear appearance.
An ophthalmic ointment preparation comprising;
- nanoparticles having one or more nonpolar meibum-like material encapsulated by at least one polyoxyethylene castor oil derivative,
- wherein the formulation exhibits a clear appearance and a viscosity>100,000 cps.
Dependencies are inferred from the claim text.