Shape-guided controlled release and retention with structures including crosslinked poly(glycerol sebacate)

A method of treatment comprising:

• orally administering a delivery system to a patient in need thereof;
• wherein the delivery system comprises a controlled release device comprising crosslinked poly(glycerol sebacate) (PGS) and a controlled release compound, the controlled release device being provided in a contracted state and expanding to a three-dimensional expanded state in a stomach of the patient;
• wherein the controlled release device is retained in the stomach by the shape of the three-dimensional expanded state;
• wherein the delivery system provides direct gastric feeding to the patient;
• and
• wherein the patient is selected from the group consisting of a dysphagic patient, a premature infant, an unconscious patient, a surgically compromised patient, and a traumatically injured patient.