Uricase gel preparation for external use, preparation method therefor and use thereof

Abstract

A uricase gel preparation for external use comprises the following components by weight: greater than 0 and less than or equal to 1.0% of uricase, 0.05-20% of an aqueous gel matrix, 0.15-20% of a protein protectant, 2-25% of a humectant, 0.01-0.20% of a chelating agent, 0.001-3.0% of a transdermal enhancer, 0.005-0.5% of a preservative and the balance of water for injection. The pH of the preparation is adjusted to 5-10 by a pH adjuster. The method for preparing the gel preparation comprises: preparing a standby substance from some of the components; respectively formulating each of the remaining components with a water for injection; adding the preservative into the standby substance and adjusting the pH; adding the protein protectant, uricase and water for injection; stirring uniformly same and then subpackaging same to obtain the gel preparation.

Dependencies are inferred from the claim text.