Devices, systems and methods for endovascular temperature control

A system configured for use in combination with a) an extracorporeal device having a heater, a cooler, a cassette-receiving area, a peristaltic pumping apparatus and a controller and b) a body heat exchanger positional on or in the body of a human or animal subject, said system comprising:

• a cassette that insertable into the cassette receiving area and Tillable with thermal exchange fluid;
• a delivery conduit that extends from the cassette and is connectable to an inflow port of the body heat exchanger;
• a return conduit that extends from the cassette and is connectable to an outflow port of the body heat exchanger;
• and
• peristaltic pump tubing that extends from the cassette and is positionable in the peristaltic pumping apparatus while the cassette is positioned in the cassette receiving area;
• whereby, when the delivery conduit is connected to an inflow port of the body heat exchanger, the outflow conduit is connected to an outflow conduit of the body heat exchanger and the peristaltic pump tubing is positioned in the peristaltic pumping apparatus, the peristaltic pump tubing is compressible by the peristaltic pumping apparatus to cause thermal exchange fluid to circulate from the cassette, through the delivery conduit, into the inflow port of the body heat exchanger, out of the outflow port of the body heat exchanger, through the outflow conduit and back into the cassette.