Circulating biomarker levels for diagnosis and risk-stratification of traumatic brain injury
AssigneeBrainbox Solutions, Inc.
InventorsDonna J. EDMONDS, Timothy E. VAN METER, NaZanin MIRSHAHI
Life of this patent
Estimating the term…
Abstract
Methods, compositions and kits useful in the diagnosis, prognosis and/or assessment of brain injuries and risk for brain injuries, such as hemorrhage, are based upon detection of certain biomarkers.
Claims21
1-60. (canceled)
A method of measuring the levels of biomarker proteins in a biological sample from a human patient that has or is suspected of having a brain injury, the method comprising:
- (a) measuring levels of biomarker proteins Neurogranin (NRGN) and Synuclein Beta (SNCB) in the biological sample;
- (b) detecting a changed level of NRGN, and a changed level of SNCB relative to reference levels;
- and
- (c) administering treatment for a brain injury when an increased level of NRGN and a decreased level of the SNCB is detected.
The method of claim 1, further comprising stratifying the patient as having a high, medium, or low risk of brain injury, and/or sequelae thereof, when an increased level of NRGN and a decreased level of SNCB relative to their respective reference levels are detected.
A method of measuring the levels of biomarker proteins in a biological sample from a human patient that has or is suspected of having a brain injury, the method comprising:
- (a) measuring levels of the biomarker proteins Neurogranin (NRGN) and/or Neuron Specific Enolase (NSE), and Synuclein Beta (SNCB) in the biological sample;
- (b) detecting a changed level of:
- (i) NRGN and/or NSE relative to a respective reference level of NSE and/or NRGN;
- and
- (ii) SNCB relative to a reference level of SNCB;
- (c) stratifying the patient as having a high, medium, or low risk of brain injury, and/or sequelae thereof, when an increased level of NRGN and/or NSE, and a decreased level of SNCB relative to their respective reference levels;
- and
- (d) administering treatment for a brain injury when the patient has a high or medium risk of brain injury.
Dependencies are inferred from the claim text.