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US 2022/0025465 A1Published application
Systems and methods for characterizing and treating cancer
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsAdam Watson-Hurthig, Ghassan Mouneimne, Casey Romanoski, Adam Grant, Megha Padi
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Abstract
Provided herein are compositions and methods for characterizing and treating cancer. In particular, provided herein are compositions and methods for identifying subjects with breast cancer with increased likelihood of bone metastasis and providing treatment to prevent such metastases.
Claims19
A method of characterizing breast cancer, comprising:
- determining a mechanical conditioning (MeCo) score in a breast cancer sample from a subject, wherein said MeCo score comprises the average expression of at least five stiff genes from any one of Tables 2-3 and 7-12 minus the average expression of at least five soft genes from any one of Tables 2-3 and 7-12.
A method of treating breast cancer, comprising:
- a) determining a mechanical conditioning (MeCo) score in a breast cancer sample from a subject, wherein said MeCo score comprises the average expression of at least five stiff genes from any one of Tables 2-3 and 7-12 minus the average expression of at least five soft genes from any one of Tables 2-3 and 7-12;
- and
- b) treating said subject with an agent that prevents bone metastatis when said MeCo score is high and not treating said subject with an agent that prevents bone metastasis when said MeCo score is low.
(canceled)
A composition, kit, or system, comprising:
- a) a plurality of nucleic acid reagents for specifically detecting the level of expression of at least 5 stiff genes from any one of Tables 2-3 and 7-12;
- and
- b) a plurality of nucleic acid reagents for specifically detecting the level of expression of at least 5 soft genes from any one of Tables 2-3 and 7-12.
19-20. (canceled)
Dependencies are inferred from the claim text.