Oligomer-conjugate complexes and their use

An oligomeric compound comprising an oligonucleotide consisting of 10-30 linked nucleosides and at least one conjugate group, wherein the oligonucleotide comprises at the 5′ position a moiety having one of the formulas:

• wherein:
• T1 is a phosphorus moiety having the formula:
• wherein:
• Ra and Rc are each, independently, OH, SH, protected hydroxyl, protected thiol, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy, amino or substituted amino;
• Rb is O or S;
• and
• Q1 and Q2 are each, independently, H, halogen, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, or substituted C1-C6 alkoxy;
• each substituted group comprises one or more optionally protected substituent groups independently selected from halogen, OJ1, N(J1)(J2), =NJ1, SJ1, N3, CN, OC(═X2)J1, OC(═X2)N(J1)(J2) and C(═X2)N(J1)(J2);
• X2 is O, S or NJ3;
• and
• J1, J2 and J3 are each, independently, H or C1-C6 alkyl.