Compositions and methods for treating cancer
AssigneeThe Children's Hospital of Philadelphia
InventorsIan Henrich, Margaret M. Chou
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treating cancer are provided. In accordance with the instant invention, methods of inhibiting or treating cancer, particularly a “cold” cancer or a cancer lacking CD8+ tumor infiltrating lymphocytes (TILs) and/or other immunostimulatory features, in a subject are provided. In a particular embodiment, the method comprises administering an agent which increases ubiquitin-specific protease 6 (USP6) activity and/or expression to the subject.
Claims30
A method of treating cancer in a subject in need thereof, said method comprising administering an agent which increases ubiquitin-specific protease 6 (USP6) activity to said subject.
(canceled)
(canceled)
(canceled)
(canceled)
A USP6 encoding nucleic acid molecule, wherein said nucleic acid molecule is an mRNA, and wherein said mRNA comprises at least one modified or non-natural base.
(canceled)
(canceled)
Dependencies are inferred from the claim text.