Bispecific antigen binding molecules comprising lipocalin muteins
AssigneeHoffmann-La Roche Inc.
InventorsChristina CLAUS, Claudia FERRARA KOLLER, Christian KLEIN, Pablo UMAÑA
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Abstract
The invention relates to bispecific antigen binding molecule capable of bivalent binding to 4-1BB and monovalent binding to a target cell antigen comprising two lipocalin muteins capable of specific binding to 4-1BB and their use in the treatment of cancer or infectious diseases.
Claims32
A bispecific antigen binding molecule capable of bivalent binding to 4-1BB and monovalent binding to a target cell antigen, comprising
- (a) an antigen binding domain capable of specific binding to a target cell antigen,
- (b) an Fc domain composed of a first and a second subunit capable of stable association, and
- (c) two lipocalin muteins capable of specific binding to 4-1BB, wherein one of the lipocalin muteins is fused to the C-terminus of the first subunit of the Fc domain and the other is fused to the C-terminus of the second subunit of the Fc domain.
A bispecific antigen binding molecule capable of bivalent binding to 4-1BB and monovalent binding to a target cell antigen, comprising
- (a) a Fab fragment comprising an antigen binding domain capable of specific binding Fibroblast Activation Protein (FAP),
- (b) an Fc domain composed of a first and a second subunit capable of stable association, and
- (c) two lipocalin muteins capable of specific binding to 4-1BB, wherein one of the lipocalin muteins is fused to the C-terminus of the first subunit of the Fc domain and the other is fused to the C-terminus of the second subunit of the Fc domain.
A bispecific antigen binding molecule capable of bivalent binding to 4-1BB and monovalent binding to a target cell antigen, comprising
- (a) a Fab fragment comprising an antigen binding domain capable of specific binding to HER2,
- (b) an Fc domain composed of a first and a second subunit capable of stable association, and
- (c) two lipocalin muteins capable of specific binding to 4-1BB, wherein one of the lipocalin muteins is fused to the C-terminus of the first subunit of the Fc domain and the other is fused to the C-terminus of the second subunit of the Fc domain.
Dependencies are inferred from the claim text.