Humanized and Affinity-Matured Anti-CEACAM1 Antibodies

An antibody or antigen-binding fragment thereof which binds to CEACAM1, the antibody or antigen-binding fragment comprising a heavy chain variable region and a light chain variable region, wherein each of the heavy chain and the light chain variable regions comprises a CDR1, CDR2, and CDR3 and wherein:

• the sequence of CDR1H comprises the sequence SHGMS (SEQ ID NO:9);
• the sequence of CDR2H comprises the sequence TISSGGTYTYYPDSVKG (SEQ ID NO:2);
• the sequence of CDR3H comprises the sequence HDFDYFPYWFAH (SEQ ID NO:10);
• the sequence of CDR1L comprises the sequence RANSAVSYMY (SEQ ID NO:4);
• the sequence of CDR2L comprises the sequence LTSNRAT (SEQ ID NO:5);
• and
• the sequence of CDR3L comprises the sequence QQWSSNPPT (SEQ ID NO:11).