Methods for treating spinal cord injury and pain

A method of treating a spinal cord injury in a subject in need thereof, the method comprising administering a therapeutically effective amount of a monoclonal anti-Repulsive Guidance Molecule A (RGMa) antibody, wherein the antibody comprises

• a. a variable heavy chain comprising a complementarity determining region (VH CDR)-1 comprising an amino acid sequence of SEQ ID NO:1, a VH CDR-2 comprising an amino acid sequence of SEQ ID NO:2, and a VH CDR-3 comprising an amino acid sequence of SEQ ID NO:3;
• and
• b. a variable light chain comprising a complementarity determining region (VL CDR)-1 comprising an amino acid sequence of SEQ ID NO:4, a VL CDR-2 comprising an amino acid sequence of SEQ ID NO:5, and a VL CDR-3 comprising an amino acid sequence selected from the group consisting of SEQ ID NO:6 and SEQ ID NO:7.