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US 2022/0025028 A1Published application
Methods of Treating or Preventing Periodontitis and Diseases Associated with Periodontitis
OwnerGeorgios Hajishengallis, John D. Lambrisinventors
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Abstract
The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.
Claims13
1-13. (canceled)
A method of treating periodontitis in an individual, comprising:
- (a) identifying an individual suffering from periodontitis;
- (b) administering to the individual a complement inhibitor comprising a Factor D inhibitor or an anti-Factor D antibody;
- and
- (c) measuring one or more of periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual;
- wherein the administering of the complement inhibitor results in a reduction in periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual as compared to periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual measured prior to administering of the complement inhibitor, thereby treating the periodontitis.
2 more elements
A method of reducing the amount of Porphyromonas gingivalis and/or the inflammation caused by P. gingivalis in an individual, comprising:
- (a) identifying an individual in which reduction in the amount of P. gingivalis is needed or desired;
- (b) administering to the individual a complement inhibitor comprising a Factor D inhibitor or an anti-Factor D antibody;
- and
- (c) measuring one or more of periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual;
- wherein the administering of the complement inhibitor results in a reduction in periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual as compared to periodontal bone loss or periodontal ligament fiber loss or P. gingivalis CFU in the individual measured prior to administering of the complement inhibitor, thereby indicating a reduction in the amount of P. gingivalis in the individual.
2 more elements
Dependencies are inferred from the claim text.