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US 2022/0024989 A1Published application
Alphavirus NSP Mutants as Vaccines
AssigneesAgency for Science, Technology and Research, University of Tartu
InventorsLisa Fong Poh Ng, Yi Hao Chan, Andres Merits, Age Utt
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Abstract
Provided herein are polypeptides, polynucleotides, expression vectors, infectious clones, virus particles and immunogenic compositions of recombinant alphaviruses which can be used as vaccines. Also provided are methods for eliciting an immune response against alphavirus infection using the immunogenic composition comprising the alphavirus mutants described herein.
Claims12
A polynucleotide encoding a recombinant polypeptide comprising the amino acid sequence set out in SEQ ID NO:
- 1, or a variant thereof, comprising one or more mutations selected from the group consisting of:
- (a) a mutation at a position equivalent to amino acid position 532 of SEQ ID NO:
- 1, and
- (b) a mutation at a position equivalent to amino acid position 1050 of SEQ ID NO:
- 1.
2 more elements
(canceled)
-29. (canceled)
Dependencies are inferred from the claim text.