Compounds and Their Use for Reducing Uric Acid Levels

A compound selected from the group consisting of

• a) compounds having a structure represented by Formula (I):
• wherein
• W is selected from O, S, and NR2, Y is selected from OH and N(R2)2, X is selected from O, S, and NR2;
• T is —CONR2—, —C(NR2)NH—, —C(NOR2)NH—, —C(N—NR2)NH—, —C(SR2)N—, or —NHC(O)—;
• A is phenyl, heteroaryl, C5-C10 branched or unbranched cycloalkyl, C6-C10 bicycloalkyl or C5-C10 spirocycloalkyl;
• each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)gR3 where g is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2N(R2)2, —NR2SO2R3, —NR2SO2N(R2)2 or —NR2C(O)N(R2)2, —C(O)NHOR2, alkyl, aryl, alkenyl and alkynyl;
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• wherein a, b, c, d, and e are each independently carbon or nitrogen, or four of a, b, c, d, and e are each independently carbon or nitrogen and one of a, b, c, d, and e is O, with the proviso that at least one of a, b, c, d and e is nitrogen, and Z is not connected directly to nitrogen or oxygen;
• and
• tautomers thereof,
• b) compounds having a structure represented by Formula (III):
• wherein
• W is selected from O, S, and NR2, Y is selected from OH and N(R2)2, X is selected from O, S, and NR2;
• each R2 is independently H, alkyl or aryl;
• and
• f is divalent —CR2—, —C(O)—, —SR2, —S(O)g— where g is 1 or 2, —N(R′)2—;
• or —C(—O(CR2)nO—)— where n=2-3;
• and
• tautomers thereof,
• c) compounds having a structure represented by Formula (IV):
• wherein
• W is selected from O, S, and NR2, Y is selected from OH and N(R2)2, X is selected from O, S, and NR2;
• each R2 is independently H, alkyl or aryl;
• and
• f is divalent —CR2—, —C(O)—, —S(O)g— where g is 1-2, —N(R2)2—;
• or —C(—O(CR2)no-)- where n is 2-3;
• and
• tautomers thereof,
• d) compounds having a structure represented by Formula (V):
• wherein
• W is selected from O, S, and NR2, Y is selected from OH and N(R2)2, X is selected from O, S, and NR2;
• and
• each R2 is independently H, alkyl or aryl;
• and
• tautomers thereof,
• e) compounds having a structure represented by Formula (VI):
• wherein
• W and X are each independently O, S, NR2 or N(R2)2;
• A is phenyl, heteroaryl, C5-C10 branched or unbranched cycloalkyl, C6-C10 bicycloalkyl or C5-C10 spirocycloalkyl;
• each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)gR3 where g is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2N(R2)2, —NR2SO2R3, —NR2SO2N(R2)2 or —NR2C(O)N(R2)2, —C(O)NHOR2, alkyl, aryl, alkenyl and alkynyl;
• U is —O—, —S—, —NR2— or —S(O)g— where g is 1 or 2;
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• wherein a, b, c, d, and e are each independently carbon or nitrogen, or four of a, b, c, d, and e are each independently carbon or nitrogen and one of a, b, c, d, and e is O, with the proviso that at least one of a, b, c, d and e is nitrogen, and Z is not connected directly to nitrogen or oxygen;
• and
• tautomers thereof,
• f) compounds having a structure represented by Formula (VII):
• wherein
• X and Y are each independently O, S, NR2 or N(R2)2;
• Z is present or absent and, if present, is selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)gR3 where g is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2N(R2)2, —NR2SO2R3, —NR2SO2N(R2)2 or —NR2C(O)N(R2)2, —C(O)NHOR2, alkyl, aryl, alkenyl and alkynyl,
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• wherein a, b, c, d, and e are each independently carbon or nitrogen, or four of a, b, c, d, and e are each independently carbon or nitrogen and one of a, b, c, d, and e is O, with the proviso that at least one of a, b, c, d and e is nitrogen, and Z is not connected directly to nitrogen or oxygen;
• and
• tautomers thereof, and
• g) compounds having a structure represented by Formula (VIII):
• wherein
• W, X, and Y are each independently O, S, NR2 or N(R2)2;
• T is —CONR2—, —C(NR2)NH—, —C(NOR2)NH—, —C(N—NR2)NH—, —C(SR2)N—, or —NHC(O)—;
• A is phenyl, heteroaryl, C5-C10 branched or unbranched cycloalkyl, C6-C10 bicycloalkyl or C5-C10 spirocycloalkyl;
• each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OR2, —C(O)R2, SR2, —S(O)gR3 where g is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2N(R2)2, —NR2SO2R3, —NR2SO2N(R2)2 or —NR2C(O)N(R2)2, —C(O)NHOR2, alkyl, aryl, alkenyl and alkynyl;
• wherein each R2 is independently H, alkyl or aryl;
• wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2;
• and
• tautomers thereof.