Recombinant mumps virus vaccine expressing genotype g fusion and hemagglutinin-neuraminidase proteins
AssigneeThe U.S.A., as represented by the Secretary, Department of Health and Human Services
InventorsSteven A. Rubin, Trent J. Bosma, Christian J. Sauder, Tahir H. Malik
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Abstract
A recombinant, attenuated mumps virus is described. The recombinant virus is based on the genotype A Jeryl Lynn vaccine strain, but is modified to express genotype G consensus fusion (F) and hemagglutinin-neuraminidase (HN) proteins. The recombinant virus optionally includes a mutation that prevents expression of viral protein V. The recombinant mumps virus can be used as a vaccine to inhibit mumps virus infection and the development of mumps disease.
Claims32
An isolated nucleic acid molecule comprising a cDNA sequence encoding a mumps virus nucleoprotein (N) gene, a mumps virus phosphoprotein (P) gene, a mumps virus matrix protein (M) gene, a mumps virus fusion protein (F) gene, a mumps virus small hydrophobic protein (SH) gene, a mumps virus hemagglutinin-neuraminidase protein (HN) gene and a mumps virus large protein (L) gene, wherein the N, P, M, SH and L genes comprise Jeryl Lynn strain mumps virus gene sequences, and the F and HN genes comprise genotype G mumps virus gene sequences.
8-13. (canceled)
A recombinant mumps virus, wherein the genome of the recombinant mumps virus comprises a nucleoprotein (N) gene, a phosphoprotein (P) gene, a matrix protein (M) gene, a fusion protein (F) gene, a small hydrophobic protein (SH) gene, a hemagglutinin-neuraminidase protein (HN) gene and a large protein (L) gene, wherein the N, P, M, SH and L genes comprise Jeryl Lynn strain mumps virus gene sequences, and the F and HN genes comprise genotype G mumps virus gene sequences.
25-30. (canceled)
39-40. (canceled)
Dependencies are inferred from the claim text.