Treatment of cachexia using fibroblast cells and products thereof
AssigneeFigene, LLC
InventorsPete O'Heeron, Thomas Ichim
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Abstract
Embodiments of the disclosure concern methods and compositions related to treatment of cachexia or inflammation related thereto. In specific embodiments, cachexia or inflammation related thereto is to treated or prevented by the administration of fibroblasts. In specific embodiments, the fibroblasts are amniotic-derived fibroblasts.
Claims14
A method for ameliorating cachexia, or inflammation related thereto, in an individual, comprising the steps of:
- a. optionally culturing a population of fibroblasts under suitable conditions to induce production of immune-modulating activity, thereby producing immune-modulating fibroblasts;
- and
- b. administering an effective amount of immune-modulating fibroblasts to the individual.
The method of claim, wherein said fibroblasts express detectable levels of one or more markers selected from the group consisting of SSEA3, SSEA4, Tra-1-60, Tra-1-81, Tra-2-54, Oct-4, CD13, CD44, CD49b, CD105, aminopeptidase N, and a combination thereof.
A method of increasing the weight of an individual with cachexia or at risk of having cachexia, comprising the step of administering an effective amount of fibroblasts to the individual.
Dependencies are inferred from the claim text.